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如前所述，自身免疫性胃炎诊断标准应沿着证明为自身免疫性疾病和证实胃内靶器官损伤的思路去改进。
现有研究表明，抗壁细胞抗体和抗内因子抗体并不直接作用于壁细胞产生破坏作用，而仅是发病机制中产生的特殊抗体作为一种诊断标志物被应用 ［13］ 。因此在证实“自身免疫性胃炎是自身免疫性疾病”方面，抗壁细胞抗体和抗内因子抗体特异性较好，敏感性尚不足 ［1］ 。在机制上，从胃壁细胞上的H + -K + -ATP酶被CD4 + T细胞破坏，刺激浆细胞产生抗壁细胞抗体和抗内因子抗体的环节中，寻找更上游的高敏感性生物标志物是可能的研究方向。
在证实胃内靶器官损伤方面，对内镜下显著的以胃体、胃底为主的重度黏膜萎缩，识别起来相对容易。早期自身免疫性胃炎的内镜下识别目前还是难点，积极寻找其内镜下特征则是另一研究方向。
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