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回顾自身免疫性胃炎发展简史，有以下几点启示。
第一，从恶性贫血到发明肝脏疗法，到发现维生素B 12 ，这个过程堪称现代医学从临床到基础再到临床研究的典范。
起始于对当时的不治之症——恶性贫血的研究。在对恶性贫血治疗的探索过程中，发现摄入肝脏可用于治疗恶性贫血，进而在此基础上发现维生素B 12 。在对恶性贫血尸检中发现了胃萎缩的现象，而使当时的研究者关注到胃酸的缺乏。Castle基于前人研究结果得出推论“恶性贫血是一种营养素缺乏性疾病”，进行了一系列实验，并提出外因子和内因子假说。其后多位医学家开展一系列研究证实了上述假说。这个过程堪称现代医学从临床到基础再到临床研究的典范。在对恶性贫血研究的这一过程所取得的研究成果两获诺贝尔奖，即是最佳证明。这个从临床到基础再到临床的过程是一个总结疾病现象、提出假说、开展相关研究、验证或否认假说、再提出新假说进行验证或否认的过程，类似于现代医院管理中PDCA（计划、执行、检查、行动）循环上升的过程，这正是现代医学不断前进的源泉，值得现代中医借鉴。笔者在某次参加一网络病例讨论会时，主持人说：“（现代医学某一疾病）目前的分类还有缺陷，随着研究的深入，不断去否定前面的分类，使之更完善、优化。”这句话让我想到了中医和西医的区别。相较于现代医学不断否认的过程，我们中医学则更多是反过来，多数情况下是遵古，不断打补丁去完善古人的观点，否定得不多，导致中医学理论体系越来越庞杂，负重前行，也使得中医初学者难以入门，或许成名的中医才能做到去伪存真，返璞归真。
第二，对一个疾病的研究要有整体观，在技术尚无法实现的情况下要有前卫的观念。
内因子学说提出后，对恶性贫血的研究更多关注到胃，客观上推动了对胃的深入研究，促进了胃炎分类学的进步。随着科学技术的突飞猛进，抗内因子抗体、抗壁细胞抗体相继被成功制备，恶性贫血、A型胃炎与自身免疫的关系得到关注。在抗内因子抗体、抗壁细胞抗体制备成功后不久（1963年）即有专家提出“恶性贫血是一种自身免疫性疾病”的观点 ［36］ 。1973 年A型胃炎概念应运而生，作者在提出A型胃炎、B型胃炎分类时，建议将萎缩性胃炎的各种并发症和后遗症按照这两种类型联系起来考虑。“恶性贫血是一种自身免疫性疾病”“将萎缩性胃炎的各种并发症和后遗症按照A型、B型胃炎联系起来考虑”，这两种观点在当时无疑是超前的。正是在这种前卫的观点下，后续的相关研究得以证实，将本病从自身免疫的角度得以阐释。
第三，从病因分类提升了慢性胃炎的系统认知。
自A型、B型胃炎分类提出后，相继出现了多种分类方法。在这些分类方法中，A型、B型胃炎分类法是根据胃的形态学和功能提出的；Correa则是基于临床、病理和病因提出慢性胃炎分类方法；其后的多种分类方法也是基于上述角度进行分类。2015 年的幽门螺杆菌胃炎京都全球共识报告只选择了病因这一维度进行分类，删繁就简，更有利于慢性胃炎的系统性认知。当然能提出基于病因的分类方法，也是近年对慢性胃炎病因研究取得明显进步的前提下，水到渠成，提出这一分类方法。
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