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三 芳维A酸氨丁三醇(arotinoid trometamol)

9名健康志愿者单次口服40μg芳维A酸氨丁三醇后,芳维A酸氨丁三醇在人体内迅速游离成芳维A酸和氨丁三醇盐,芳维A酸的t max 和C max 分别是2.5±1.7h和985±369pg/mL。t 1/2 是16.2±9.0 h,AUC 0- t和AUC 0-∞ 分别是18.6±12.3和19.8±13.3ng·h/mL。

参考文献

[1]DENG P,CHEN X,TANG Y,et al.Determination of arotinoid acid in human plasma by liquid chromatography-tandem mass spectrometry [J]. J Chromatogr B analyt technol biomed life sci,2009,877(27):2983-2988.

[2]WANG Y,ZOLFAGHARI R,ROSS A C.Cloning of rat cytochrome P450RAI(CYP26)cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo [J]. Arch biochem biophys,2002,401(2):235-243.

[3]REGAZZI M B,IACONA I,GERVASUTTI C,et al.Clinical pharmacokinetics of tretinoin[J]. Clin pharmacokinet,1997,32(5):382-402.

[4]CONLEY B A,EGORIN M J,SRIDHARA R,et al.Phase Ⅰ clinical trial of all-trans-retinoic acid with correlation of its pharmacokinetics and pharmacodynamics [J]. Cancer chemother pharmacol,1997,39(4):291-299.

[5]ZHOU D C,HALLAM S J,LEE S J,et al.Constitutive expression of cellular retinoic acid binding protein Ⅱ and lack of correlation with sensitivity to all-trans retinoic acid in acute promyelocytic leukemia cells [J]. Cancer res,1998,58(24):5770-5776.

[6]LAZZARINO M,CORSO A,REGAZZI M B,et al.Modulation of all-trans retinoid acid pharmacokinetics in acute promyelocytic leukaemia by prolonged interferon-alpha therapy[J]. Br J haematol,1995,90(4):928-930.

[7]BLAIR H A,SCOTT L J.Alitretinoin:a review in severe chronic hand eczema [J]. Drugs,2016,76(13):1271-1279.

[8]SCHMITT-HOFFMANN A H,ROOS B,SAUER J,et al.Pharmacokinetics,efficacy and safety of alitretinoin in moderate or severe chronic hand eczema [J]. Clin exp dermatol,2011,36(Suppl 2):29-34.

[9]SCHMITT-HOFFMANN A H,ROOS B,SAUER J,et al.Low levels of alitretinoin in seminal fluids after repeated oral doses in healthy men [J]. Clin exp dermatol,2011,36(Suppl 2):12-17.

[10]THYSSEN J P,VESTER L,GRNHJ L C,et al.The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis [J]. Br J dermatol,2014,170(2):408-414.

[11]ADAMSON P C,WIDEMANN B C,REAMAN G H,et al.A phase Ⅰ trial and pharmacokinetic study of 9-cis-retinoic acid(ALRT1057)in pediatric patients with refractory cancer:a joint Pediatric Oncology Branch,National Cancer Institute,and Children's Cancer Group study [J]. Clin cancer res,2001,7(10):3034-3039.

[12]WEBER C,DUMONT E.Pharmacokinetics and pharmacodynamics of 9-cis-retinoic acid in healthy men [J]. J clin pharmacol,1997,37(7):566-574.

[13]MILLER V A,RIGAS J R,BENEDETTI F M,et al.Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid [J]. Clin cancer res,1996,2(3):471-475.

[14]SCHMITT-HOFFMANN A H,ROOS B,SAUER J,et al.Influence of alitretinoin on the pharmacokinetics of the oral contraceptive ethinyl estradiol/norgestimate [J]. Clin exp dermatol,2011,36(Suppl 2):4-11.

[15]FORMELLI F,CAVADINI E,MASCHERONI L,et al.Pharmacokinetics and effects on plasma retinol concentrations of 13-cis-retinoic acid in melanoma patients [J]. Br J cancer,1997,76(12):1655-1660.

[16]WAKELEE H A,MIDDLETON G,DUNLOP D,et al.A phase Ⅰ pharmacokinetic study of bexarotene with vinorelbine and cisplatin in patients with advanced non-small-cell lung cancer(NSCLC)[J]. Cancer chemother pharmacol,2012,69(3):815-824.

[17]HOWELL S R,SHIRLEY M A,GRESE T A,et al.Bexarotene metabolism in rat,dog,and human,synthesis of oxidative metabolites,and in vitro activity at retinoid receptors[J]. Drug metab dispos,2001,29(7):990-998.

[18]TANG-LIU D D,MATSUMOTO R M,USANSKY J I.Clinical pharmacokinetics and drug metabolism of tazarotene:a novel topical treatment for acne and psoriasis [J]. Clin pharmacokinet,1999,37(4):273-287.

[19]SIDGIDDI S,ALLENBY K,OKUMU F,et al.Bioavailability,pharmacokinetics,and transepidermal water loss of short contact tazarotene lotion 0.1% versus tazarotene(tazorac(®))cream 0.1 [J]. J clin aesthet dermatol,2019,12(9):16-24.

[20]Jones P H,Burnett R D,Fainaru I,et al.A phase Ⅰ study of tazarotene in adults with advanced cancer [J]. Br J cancer,2003,89(5):808-815.

[21]HAMADA T,SUGAYA M,TOKURA Y,et al.Phase Ⅰ/Ⅱ study of the oral retinoid X receptor agonist bexarotene in Japanese patients with cutaneous T-cell lymphomas [J]. J dermatol,2017,44(2):135-142.

[22]RODON J,JACOBS C D,CHU Q,et al.A phase Ⅰ pharmacokinetic study of bexarotene with paclitaxel and carboplatin in patients with advanced non-small cell lung cancer(NSCLC)[J]. Cancer chemother pharmacol,2012,69(3):825-834.

[23]李秀玉.维胺酯治疗寻常痤疮研究进展[J].中国临床医生,2010,38(4):25-27.

[24]尹兴平.方希的不良反应及处理[J].现代医药卫生,2008,24(12):1833-1835.

[25]漆小清,缪金明,方智雯,等.全反式维甲酸的临床药代动力学研究[J].中华血液学杂志,1994,15(2):70-72.

(马鹏程 张锡宝) 3+HrXEKAWU42ucJSd5zVIcGbdbeXK2WnV71Z5oPzwShZW4jh8kLDPBJYFb7btEUp

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