参考文献

[1] BEHNKE MS，RADKE JB，SMITH AT，et al. The transcription of bradyzoite genes in Toxoplasma gondii is controlled by autonomous promoter elements［J］. Mol Microbiol，2008，68（6）：1502-1518.

[2] BEHNKE MS，WOOTTON JC，LEHMANN MM，et al. Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii ［J］. PLoS One，2010，5（8）：e12354.

[3] BHATTI MM，LIVINGSTON M，MULLAPUDI N，et al. Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii ［J］. Eukaryot Cell，2006，5（1）：62-76.

[4] BOUGDOUR A，BRAUN L，CANNELLA D，et al. Chromatin modifications：implications in the regulation of gene expression in Toxoplasma gondii ［J］. Cell Microbiol，2010，12（4）：413-423.

[5] BRAUN L，CANNELLA D，PINHEIRO AM，et al. The small ubiquitin-like modifier（SUMO）-conjugating system of Toxoplasma gondii ［J］. Int J Parasitol，2009，39（1）：81-90.

[6] BRAUN L，CANNELLA D，ORTET P，et al. A complex small RNA repertoire is generated by a plant/fungal-like machinery and effected by a metazoan-like argonaute in the single-cell human parasite Toxoplasma gondii ［J］. PLoS Pathog，2010，6（5）：e1000920.

[7] CANNELLA D，BRENIER-PINCHART MP，BRAUN L，et al. miR-146a and miR-155 delineate a microRNA fingerprint associated with Toxoplasma persistence in the host brain［J］. Cell Rep，2014，6（5）：928-937.

[8] DALMASSO MC，ONYANGO DO，NAGULESWARAN A，et al. Toxoplasma H2A variants reveal novel insights into nucleosome composition and functions for this histone family［J］. J Mol Biol，2009，392（1）：33-47.

[9] DESHMUKH AS，MITRA P AND MARUTHI M. Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii ［J］. Sci Rep，2016，6：35288.

[10] DESHMUKH AS，MITRA P，KOLAGANI A，et al. Cdk-related kinase 9 regulates RNA polymerase II mediated transcription in Toxoplasma gondii ［J］. Biochim Biophys Acta Gene Regul Mech，2018，1861（6）：572-585.

[11] DIXON SE，STILGER KL，ELIAS EV，et al. A decade of epigenetic research in Toxoplasma gondii ［J］. Mol Biochem Parasitol，2010，173（1）：1-9.

[12] ERNST A，CAMPOS B，MEIER J，et al. De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures［J］. Oncogene，2010，29（23）：3411-3422.

[13] FOX BA AND BZIK DJ. De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii ［J］. Nature，2002，415（6874）：926-929.

[14] GISSOT M，KELLY KA，AJIOKA JW，et al. Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii ［J］. PLoS Pathog，2007，3（6）：e77.

[15] GRANADOS-RIVERON，JT AND AQUINO-JARQUIN G. The complexity of the translation ability of circRNAs［J］. Biochim Biophys Acta，2016，1859（10）：1245-1251.

[16] GUTTMAN M AND RINN JL. Modular regulatory principles of large non-coding RNAs［J］. Nature，2012，482（7385）：339-346.

[17] HANQUIER J，GIMENO T，JEFFERS V，et al. Evaluating the GCN5b bromodomain as a novel therapeutic target against the parasite Toxoplasma gondii ［J］. Exp Parasitol，2020，211：107868.

[18] HARRIS MT，JEFFERS V，MARTYNOWICZ J，et al. A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii ［J］. Mol Biochem Parasitol，2019，232：111203.

[19] HONG DP，RADKE JB AND WHITE MW. Opposing transcriptional mechanisms regulate Toxoplasma development［J］. mSphere，2017，2（1）：e00347.

[20] HONG X，ZANG J，WHITE J，et al. Interaction of JMJD6 with single-stranded RNA［J］. Proc Natl Acad Sci U S A，2010，107（33）：14568-14572.

[21] HUANG S，HOLMES MJ，RADKE JB，et al. Toxoplasma gondii AP2IX-4 regulates gene expression during bradyzoite development［J］. mSphere，2017，2（2）：e00054-17.

[22] JEFFERS V AND SULLIVAN WJ. Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii ［J］. Eukaryot Cell，2012，11（6）：735-742.

[23] LAI BS，WITOLA WH，EL BK，et al. Molecular target validation，antimicrobial delivery，and potential treatment of Toxoplasma gondii infections［J］. Proc Natl Acad Sci USA，2012，109（35）：14182-14187.

[24] LESAGE KM，HUOT L，MOUVEAUX T，et al. Cooperative binding of ApiAP2 transcription factors is crucial for the expression of virulence genes in Toxoplasma gondii ［J］. Nucleic Acids Res，2018，46（12）：6057-6068.

[25] LISTER R，PELIZZOLA M，DOWEN RH，et al. Human DNA methylomes at base resolution show widespread epigenomic differences［J］. Nature，2009，462（7271）：315-322.

[26] MOUVEAUX T，ORIA G，WERKMEISTER E，et al. Nuclear glycolytic enzyme enolase of Toxoplasma gondii functions as a transcriptional regulator［J］. PLoS One，2014，9（8）：e105820.

[27] MULLAPUDI N，JOSEPH SJ AND KISSINGER JC. Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gondii ［J］. Genome Biol，2009，10（4）：R34.

[28] RADKE JB，LUCAS O，DE SILVA EK，et al. ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst［J］. Proc Natl Acad Sci U S A，2013，110（17）：6871-6876.

[29] RADKE JB，WORTH D，HONG D，et al. Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis［J］. PLoS Pathog，2018，14（5）：e1007035.

[30] SAKSOUK N，BHATTI MM，KIEFFER S，et al. Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii ［J］. Mol Cell Biol，2005，25（23）：10301-10314.

[31] SAUTEL CF，CANNELLA D，BASTIEN O，et al. SET8-mediated methylations of histone H4 lysine 20 mark silent heterochromatic domains in apicomplexan genomes［J］. Mol Cell Biol，2007，27（16）：5711-5724.

[32] SAUTEL CF，ORTET P，SAKSOUK N，et al. The histone methylase KMTox interacts with the redox-sensor peroxiredoxin-1 and targets genes involved in Toxoplasma gondii antioxidant defences［J］. Mol Microbiol，2009，71（1）：212-226.

[33] SKARIAH S，MCINTYRE MK AND MORDUE DG. Toxoplasma gondii ：determinants of tachyzoite to bradyzoite conversion［J］. Parasitol Res，2010，107（2）：253-260.

[34] SMITH AT，TUCKER-SAMARAS SD，FAIRLAMB AH，et al. MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii ［J］. Eukaryot Cell，2005，4（12）：2057-2065.

[35] SPENKUCH F，MOTORIN Y AND HELM M. Pseudouridine：still mysterious，but never a fake（uridine）［J］. RNA Biol，2014，11（12）：1540-1554.

[36] SULLIVAN WJ AND JEFFERS V. Mechanisms of Toxoplasma gondii persistence and latency［J］. FEMS Microbiol Rev，2012，36（3）：717-733.

[37] SUVOROVA ES，CROKEN M，KRATZER S，et al. Discovery of a splicing regulator required for cell cycle progression［J］. PLoS Genet，2013，9（2）：e1003305.

[38] SUVOROVA ES AND WHITE MW. Transcript maturation in apicomplexan parasites［J］. Curr Opin Microbiol，2014，20：82-87.

[39] SZATANEK T，ANDERSON-WHITE BR，FAUGNO-FUSCI DM，et al. Cactin is essential for G1 progression in Toxoplasma gondii ［J］. Mol Microbiol，2012，84（3）：566-577.

[40] VONLAUFEN N，NAGULESWARAN A，COPPENS I，et al. MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated（ATM）kinase-mediated DNA damage response in Toxoplasma gondii ［J］. J Biol Chem，2010，285（15）：11154-11161.

[41] WALDMAN BS，SCHWARZ D，WADSWORTH MN，et al. Identification of a master regulator of differentiation in Toxoplasma ［J］. Cell，2020，180（2）：359-372.

[42] WALKER R，GISSOT M，CROKEN MM，et al. The Toxoplasma nuclear factor TgAP2XI-4 controls bradyzoite gene expression and cyst formation［J］. Mol Microbiol，2013，87（3）：641-655.

[43] WANG J，DIXON SE，TING LM，et al. Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation［J］. PLoS Pathog，2014，10（1）：e1003830.

[44] WEI H，JIANG S，CHEN L，et al. Characterization of cytosine methylation and the DNA methyltransferases of Toxoplasma gondii ［J］. Int J Biol Sci，2017，13（4）：458-470.

[45] WU X AND ZHANG Y. TET-mediated active DNA demethylation：Mechanism，function and beyond［J］. Nature Reviews Genetics，2017，18（9）：517-534.

[46] ZEINER GM，NORMAN KL，THOMSON JM，et al. Toxoplasma gondii infection specifically increases the levels of key host microRNAs［J］. PLoS One，2010，5（1）：e8742.

[47] ZHOU CX，AI K，HUANG CQ，et al. miRNA and circRNA expression patterns in mouse brain during toxoplasmosis developmen t［J］. BMC Genomics，2020，21（1）：46. Jw3AF3854OI8OUKWFfxrtK9/0IXcziPKMx/gF/Z9mRo2PntkdyaeCmXKradRS3Ic