七、甲状腺炎

1．亚急性甲状腺炎。1895年，Mygind ^[41] 报道了18名患有亚急性甲状腺炎的患者，他将该病称为“Thyroiditis Acuta”，意为“急性甲状腺炎”。9年后，瑞士医生Quervain ^[42] 描述了相似症状患者的组织病理学并称之为“非化脓性甲状腺炎”。这两者报道的都是我们今天所熟知的亚急性甲状腺炎。

2．慢性侵袭性纤维性甲状腺炎。1896年，德国外科医生Riedel ^[43] 报道了一种今天非常罕见的甲状腺炎——慢性侵袭性纤维性甲状腺炎，并且以他的名字命名。

3．桥本甲状腺炎。1912年，日本医生Hashimoto描述了今天最常见的甲状腺炎——桥本甲状腺炎。Hashimoto报道了4名患有甲状腺肿的女性，她们的甲状腺病理标本都伴有淋巴细胞浸润、实质性萎缩和纤维化 ^[44] 。

1956年，来自美国的免疫学家Rose和他的导师Witebsky解释了桥本甲状腺炎的发病机制（图1-9）。他们证明了使用同源甲状腺提取物进行免疫的兔子会产生针对甲状腺球蛋白的自身抗体，并且这些兔子的甲状腺伴有淋巴细胞浸润 ^[45] 。同年，来自英国的Doniach等 ^[46] 证实了桥本甲状腺炎患者血清中含有甲状腺球蛋白的自身抗体。

参考文献

[1] Weissel M. Highlights in thyroidology: a historical vignette[J]. Wien Klin Wochenschr, 2014, 126: 311-319.

[2] Rosenfeld L. William Prout: early 19th century physician-chemist[J]. Clin Chem, 2003, 49: 699-705.

[3] Prout W. Chemistry, meteorology, and the function of digestion, considered with reference to natural theology[M]. Carey, Lea & Blanchard Philadelphia, 1834, 75.

[4] Coindet J. Découverte d'un nouveau remède contre le goitre[J]. Annales de Chimie et Physique, 1820, 15: 49-59.

[5] Baumann E. Über das normale Vorkommen von Jod im Thierkörper. Hoppe-Seyler's Z[J]. Physiol Chem, 1895, 21: 319.

[6] Baumann E. Über das Thyrojodin[J]. Münch Med Wochenschr, 1896, 43: 309.

[7] Gley E, Bourcet P. Présence del'iode dans le sang[J]. CR Acad Sci （Paris）, 1900, 130: 1721.

[8] Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter[J]. Nature, 1996, 379: 458-460.

[9] Chatin A. Recherches sur l'iode des eaux douces; de la présence de ce corps dans les plantes at les animaux terrestes[J]. Comptes Rendus Hebdomadaires des S'eances de l'Academie des Sciences, 1851, 31 : 280-283.

[10] Zimmermann M. Research on iodine deficiency and goiter in the 19th and early 20th centuries[J]. J Nutr, 2008, 138:2060-2063.

[11] Marine D, Kimbal O. The prevention of simple goiter in man[J]. Arch Intern Med, 1920, 25: 661-672.

[12] Cranefield P, Federn W. Paracelsus on goiter and cretinism:a translation and discussion of “de struma, vulgo der Kropf”[J]. Bulletin of the History of Medicine, 1963, 37: 463-471.

[13] Cranefield P. The discovery of cretinism [J]. Bulletin of the History of Medicine, 1962, 36: 489-500.

[14] Wagner-Jauregg J. Über den Kretinismus[J]. Monatsschr Gesundheitspflege, 1898, 16: 57-68.

[15] Wagner-Jauregg J. Kropfprophylaxe durch Vollsalz[J]. Wien klin Wochenschr, 1925, 38: 1377-1380.

[16] Kendall E. The isolation in crystalline form of the compound containing iodin which occurs in the thyroid. Its chemical nature and physiologic activity[J]. JAMA, 1915, 64: 2042.

[17] Harington C. Chemistry of thyroxine Ⅱ constitution and synthesis of thyroxine [J]. Biochem J, 1927, 21: 169-183.

[18] Gross J, Pitt-Rivers R. The identification of 3, 5, 3 ′ -L_triiodothyronine in human plasma[J]. Lancet, 1952, 1:439-441.

[19] Roche J, Lissitzky S, Michel R. Sur la triiothyronine, produit intermédiaire de la transformation de la diiodothyronine en thyroxine[J]. Paris: C. R. Acad. Sci, 1952, 234: 997-998.

[20] Braverman L, Ingbar S, Sterling K. Conversion of thyroxine to triiodothyronine in athyreotic human subjects[J]. J Clin Invest, 1970, 49: 855-864.

[21] Yalow R, Berson S. Assay of plasma insulin in human subjects by immunological methods[J]. Nature, 1959, 184: 1648-1649.

[22] Bürgi H. Thyroid eye disease: a historical perspective[J]. Orbit, 2009, 28: 226-230.

[23] Parry C. Collection from the unpublished medical writings[M]. London: Underwood, 1825: 111.

[24] Graves R. Clinical lectures delivered by Robert J Graves MD at Meathhospital during the session of 1834—1835[J]. Lon surg J, 1835, 7: 516.

[25] Basedow C. Exophthalmos durch hypertrophie des Zeilgewebes in Augenhohle[J]. Wochenschr Ges Heilkunde, 1840, 13: 197-228.

[26] Magnus-Levy A. Über den respiratorischen Gaswechsel unter dem Einfluss der Thyreoidea sowie unter verschiedenen pathologischen Zuständen[J]. Berliner Klin Wochenschr, 1895, 32: 650.

[27] Adams D, Purves H. Abnormal responses in the assay of thyrotropin[J]. Proceedings of Otago Medical School, 1956, 34: 11-12.

[28] Southgate K, Creagh F, Teece M, et al. A receptor assay for the measurement of TSH receptor antibodies in unextracted serum[J]. Clin Endocrinol （Oxf）, 1984, 20:539-548.

[29] Astwood E. The chemical nature of compounds which inhibit the function of the thyroid gland[J]. J Pharmacol Exp Ther, 1943, 78: 79.

[30] Astwood E. Treatment of hyperthyroidism with thiourea and thiouracil[J]. JAMA, 1943, 122: 78-81.

[31] Hertz S, Roberts A, Evans R. Radioactive iodine as an indicator in the study of thyroid physiology[J]. Proc Soc Exper Biol Med, 1938, 38: 510.

[32] Hamilton J, Soley M. Studies in iodine metabolism of the thyroid gland by the use of radio-iodine in normal subjects and in patients with various types of goiter[J]. Am J Physiol, 1940, 131: 135.

[33] Gull W. On a cretinoid state supervening in adult life in women[J]. Trans Clin Soc Lond, 1874, 7: 180-185.

[34] Roberts C, Ladenson P. Hypothyroidism[J]. Lancet, 2004, 363: 793-803.

[35] Ord W. Report of a committee of clinical society of London nominated December 14, 1883 to investigate the subject of myxoedema[M]. Trans Clin Soc Lond, 1888, 21.

[36] Bettencourt R. Serrano J-A Un cas de myxoedème （cachexie pachydermique）traité par la greffe hypodermique du corps thyroïded'un mouton[C]. Compte rendu de la 19eme session de l‘Association française pourl'avancement des sciences, Limoges, 1890: 683-690.

[37] Murray G. Note on the treatment of myxedema by hypodermic injections of an extract of the thyroid gland of a sheep[J]. Brit med J, 1891, 796-797.

[38] Sarkar S, Banerjee S, Sarkar R, et al. A Review on the History of‘Thyroid Surgery'[J]. Indian J Surg, 2016, 78: 32-36.

[39] Becker W. Presidential address: pioneers in thyroid surgery[J]. Ann Surg, 1977, 185: 493-504.

[40] Kocher A. The treatment of hypothyroidism by thyroid transplantation[J]. Br med J, 1923, 560-561.

[41] Mygind H. Thyroiditis acuta simplex[J]. J Laryngol, 1895, 91: 181-193.

[42] De Quervain F. Die akute nicht eitrige Thyreoiditis. Mitteilungen aus den Grenzge-bieten der Medizin und Chirurgie[J]. Supplement Band, 1904, 2: 165.

[43] Riedel B. Zu Tumoren führende Entzündung der Schilddrüse[J]. Verh Dtsch Ges Chir, 1896, 25: 101-105.

[44] Hashimoto H. Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse （Struma lymphomatosa）[J]. Archiv für Klinische Chirurgie, 1912, 97: 219-248.

[45] Rose N, Witebsky E. Studies in organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts[J]. J Immunol, 1956, 76: 417-427.

[46] Campbell P, Doniach D, Hudson R, et al. Autoantibodies in Hashimoto's disease （lymphadeonoid goitre）[J]. Lancet, 1956, 271: 820-821. 25rg6QIrNP+Q6UkzL616zYLoFj3dDpOkGr4RY4HhQXHbhxVBhOBwp6KC+/6f7NVH