参考文献

［1］ANAND P，SANKARAN S，MUKHERJEE S，et al.Structural annotation of Mycobacterium tuberculosis proteome［J］.PLoS One，2011（6）:e27044.

［2］CABIBBE A M，MIOTTO P，MOURE R，et al.Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis［J］.J Clim Microbiol，2015，53（12）:3876-3880.

［3］CHHOTARAY C，TAN Y，MUGWERU J，et al.Advances in the development of molecular genetic tools for Mycobacterium tuberculosis［J］.J Genet Genomics，2018，45（6）:281-297.

［4］CHOUDHARY E，THAKUR P，PAREEK M，et al.Gene silencing by CRISPR interference in mycobacteria［J］.Nat Commun，2015（6）:6267.

［5］COLE S T，BROSCH R，PARKHILL J，et al.Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence［J］.Nature，1998，393（6685）:537-544.

［6］DENG J，BI L，ZHOU L，et al.Mycobacterium tuberculosis proteome microarray for global studies of protein function and immunogenicity［J］.Cell Rep，2014，9（6）:2317-2329.

［7］FARHAT M R，SHAPIRO B J，KIESER K J，et al.Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis［J］.Nat Genet，2013，45（10）:1183-1189.

［8］FELTCHER M E，GUNAWARDENA H P，ZULAUF K E，et al.Label-free Quantitative Proteomics Reveals a Role for the Mycobacterium tuberculosis SecA2 Pathway in Exporting Solute Binding Proteins and Mce Transporters to the Cell Wall［J］.Mol Cell Proteomics，2015（14）:1501-1516.

［9］FLENTIE K，GARNER A L，STALLINGS C L，et al.Mycobacterium tuberculosis Transcription Machinery:Ready To Respond to Host Attacks［J］.J Bacteriol，2016，198（9）:1360-1373.

［10］HEATHER J M，CHAIN B.The sequence of sequencers:The history of sequencing DNA［J］.Genomics，2016，107（1）:1-8.

［11］HUBIN E A，LILIC M，DARST S A，et al.Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures［J］.Nat Commun，2017（8）:16072.

［12］JAIN P，HSU T，ARAI M，et al.Specialized transduction designed for precise high-throughput unmarked deletions in Mycobacterium tuberculosis［J］.MBio，2014，5（3）:e01245.

［13］JHINGAN G D，KUMARI S，JAMWAL S V，et al.Comparative Proteomic Analyses of Avirulent，Virulent，and Clinical Strains of Mycobacterium tuberculosis Identify Strain-specific Patterns［J］.J Biol Chem，2016（291）:14257-14273.

［14］KUNDU M.The role of two-component systems in the physiology of Mycobacterium tuberculosis［J］.IUBMB Life，2018，70（8）:710-717.

［15］LATA M，SHARMA D，DEO N，et al.Proteomic analysis of ofloxacin-mono resistant Mycobacterium tuberculosis isolates［J］.J Proteomics，2015，127（Pt A）:114-121.

［16］LUO T，COMAS I，LUO D，et al.Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese［J］.Proc Natl Acad Sci U S A，2015，112（26）:8136-8141.

［17］MELIEF E，KOKOCZKA R，FILES M，et al.Construction of an overexpression library for Mycobacterium tuberculosis［J］.Biol Methods Protoc，2018，3（1）:009.

［18］PANKHURST LJ，ELIAS C，VOTINTSEVA A A，et al.Rapid，comprehensive，and affordable mycobacterial diagnosis with whole-genome sequencing:a prospective study［J］.Lancet Respir Med，2016，4（1）:49-58.

［19］SAWYER E B，GRABOWSKA A D，CORTES T，et al.Translational regulation in mycobacteria and its implications for pathogenicity［J］.Nucleic Acids Res，2018，46（14）:6950-6961.

［20］TANG P，WANG X，SHEN X，et al.Use of DNA microarray chips for the rapid detection of Mycobacterium tuberculosis resistance to rifampicin and isoniazid［J］.Exp Ther Med，2017，13（5）:2332-2338.

［21］TUFARIELLO J M，MALEK A A，VILCHÈZE C，et al.Enhanced specialized transduction using recombineering in Mycobacterium tuberculosis［J］.MBio，2014，5（3）:e01179.

［22］USHIO R，YAMAMOTO M，NAKASHIMA K，et al.Digital PCR assay detection of circulating Mycobacterium tuberculosis DNA in pulmonary tuberculosis patient plasma［J］.Tuberculosis（Edinb），2016（99）:47-53.

［23］VERMA R，PINTO S M，PATIL A H，et al.Quantitative Proteomic and Phosphoproteomic Analysis of H ₃₇ Ra and H ₃₇ Rv Strains of Mycobacterium tuberculosis［J］.J Proteome Res，2017，16（4）:1632-1645.

［24］FAN X，ABDALLA A A，XIE J.Distribution and function of prophage phiRv1 and phiRv2 among Mycobacterium tuberculosis complex［J］.J Biomol Struct Dyn，2016，34（2）:233-238.

［25］BAI X J，LIANG Y，YANG Y R，et al.Immune responses to latent tuberculosis antigen Rv2659c in Chinese populations［J］.J Microbiol Immunol Infect，2015，48（4）:381-389.

［26］JIANG Y，LIU H，WANG X，et al.Conserved hypothetical protein Rv1977 in Mycobacterium tuberculosis strains contains sequence polymorphisms and might be involved in ongoing immune evasion［J］.Int J Clin Exp Pathol，2015，8（6）:6891.

［27］JIANG Y，LIU H C，DOU X F，et al.Polymorphisms of human T cell epitopes of Mycobacterium tuberculosisindicate divergence of host immune pressure on different categories ofproteins［J］.Life science，2018（209）:388-394.

［28］ZHANG H，LI D，ZHAO L，et al.Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance［J］.Nat Genet，2013，45（10）:1255-1260. 7L6VUg4Uz/LfjSnHdEWN5SZCmyHhxgtBvSJE8Kj5WmtV6d1HNhlb7fO1MiqHYkBW