参考文献

［1］布坎南，吉本斯.伯杰细菌鉴定手册［M］.8版.北京：科学出版社，1984.

［2］中华医学会结核病学分会临床检验专业委员会.结核病病原学分子诊断专家共识［J］.中华结核和呼吸杂志，2018，41（ 9 ）:688-695.

［3］刘洋，王邦兴，刘志永，等.非一线抗结核药物耐药机制及耐药性诊断研究进展［J］.遗传，2016，38（10）:928-939.

［4］董娜，付玉荣，伊正君.结核分枝杆菌感染致脂代谢异常及其机制研究进展［J］.中华结核和呼吸杂志，2016，39（7）:548-550.

［5］林波，颜建国.结核分枝杆菌快速培养及药物敏感性试验的临床意义［J］.中国民族民间医药，2011，20（7）:96.

［6］WORLD HEALTH ORGANIZATION.Global Tuberculosis Report 2020［R/OL］.2020.https://www.who.int/publications/i/item/global-tuberculosis-report-2020.

［7］NIEMANN S.Diversity and Evolution of Mycobacterium tuberculosis:Moving to Whole-Genome-Based Approaches［J］.CSH PERSPECT MED，2014，4（12）:a021188.

［8］FILLIOL I，FERDINAND S，NEGRONI L，et al.Molecular typing of Mycobacterium tuberculosis based on variable number of tandem DNA repeats used alone and in association with spoligotyping［J］.Clinal Microbiol，2000，38（7）:2520-2524.

［9］WELDU Y.Comparative evaluation of a two-reagent cold stain method with Ziehl-Nelseen method for pulmonary tuberculosis diagnosis［J］.Bmc Research Notes，2013，6（1）:1-5.

［10］ALNIMR A M.Dormancy models for Mycobacterium tuberculosis:A minireview［J］.Brazilian Journal of Microbiology，2015，46（3）:641-647.

［11］BOON C，LI R，QI R，et al.Proteins of Mycobacterium bovis BCG Induced in the Wayne Dormancy Model［J］.Journal of Bacteriology，2001，183（8）:2672-2676.

［12］ZHANG Y，YEW W W.Mechanisms of drug resistance in Mycobacterium tuberculosis:update 2015［J］.The International Journal of Tuberculosis and Lung Disease，2015，19（11）:1276-1289.

［13］BRAKE L H，KNEGT G J，STEENWINKEL J E，et al.The role of efflux pumps in tuberculosis treatment and their promise as a target in drug development:unraveling the black box［J］.Annual review of pharmacology and toxicology，2018（58）:271-291.

［14］SILVA P E ，VON GROLL A，MARTIN A，et al.Efflux as a mechanism for drug resistance in Mycobacterium tuberculosis［J］.FEMS Immunology & Medical Microbiology，2011，63（1）:1-9.

［15］HAMEED H M，ISLAM M M，CHHOTARAY C，et al.Molecular Targets Related Drug Resistance Mechanisms in MDR-，XDR-，and TDR-Mycobacterium tuberculosis Strains［J］.Frontiers in cellular and infection microbiology，2018（8）:114.

［16］GILLESPIE S H.Evolution of drug resistance in Mycobacterium tuberculosis:clinical and molecular perspective［J］.Antimicrobial agents and chemotherapy，2002，46（2）:267-274.

［17］SCHÖN T，MIOTTO P，KÖSER C U，et al.Mycobacterium tuberculosis drug-resistance testing:challenges，recent developments and perspectives［J］.Clinical Microbiology and Infection，2017，23（3）:154-160.

［18］SABINE E，KYU R.Mycobacterium tuberculosis metabolism and host interaction:mysteries and paradoxes［J］.Curr Top Microbiol Immunol，2013（374）:163-188.

［19］BROWN H A，VINOGRADOV E，GILBERT M，et al.The Mycobacterium tuberculosis complex has a pathway for the biosynthesis of 4-formamido-4，6-dideoxy-d-glucose［J］.Protein Sci，2018（27）:1491-1497.

［20］HENDRIK K B，KARL S，ROBERT W，et al.Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis［J］.PLoS Pathog，2016，12（8）:e1005768.

［21］WILLIAMS K J，JENKINS V A，BARTON G R，et al.Deciphering the metabolic response of Mycobacterium tuberculosis to nitrogen stress［J］.Mol Microbiol，2015，97（6）:1142-1157.

［22］MALI P C，MEENA L S.Triacylglycerol:nourishing molecule in endurance of Mycobacterium tuberculosis［J］.Biosci，2018，43（1）:149-154.

［23］HUANG L，NAZAROVA E V，TAN S，et al.Mycobacterium tuberculosisGrowth of in vivo segregates with host macrophage metabolism and ontogeny［J］.Exp Med，2018（ 215）:1135-1152.

［24］MIAO J T，LIU H R，QU Y S，et al.Effect of peptidoglycan amidase MSMEG_6281 on fatty acid metabolism in Mycobacterium smegmatis［J］.Microb Pathog，2020（140）:103939.

［25］HATFULL G F.Mycobacteriophages:windows into tuberculosis［J］.PLoS Pathog，2014 ，10（3）:e1003953.

［26］LAMRABET O，DRANCOURT M.Genetic engineering of Mycobacterium tuberculosis:a review［J］.Tuberculosis（Edinb），2012，92（5）:365-376.

［27］CATALÃO M J，PIMENTEL M.Mycobacteriophage Lysis Enzymes:Targeting the Mycobacterial Cell Envelope ［J］.Viruses，2018，10（8）:428.

［28］JAIN P，THALER D S，MAIGA M，et al.Reporter phage and breath tests:emerging phenotypic assays for diagnosing active tuberculosis，antibiotic resistance，and treatment efficacy［J］.Infect Dis，2011，204（Suppl 4）:S1142-S1150.

［29］KESSEL J C，MARINELLI L J，HATFULL G F.Recombineering mycobacteria and their phages［J］.Nat Rev Microbiol，2008，6（11）:851-857.

［30］MCNERNEY R，TRAORÉ H.Mycobacteriophage and their application to disease control［J］.Appl Microbiol，2005，99（2）:223-233.

［31］JACOBS W R，TUCKMAN M，BLOOM B R.Introduction of foreign DNA into mycobacteria using a shuttle phasmid［J］.Nature，1987，327（6122）:532-536.

［32］MARKOVA N，MICHAILOVA L，JOURDANOVA M，et al.Exhibition of persistent and drug-tolerant L-form habit of Mycobacterium tuberculosis，during infection in rats［J］.Open Life Sciences，2008，3（4）:407-416.

［33］PIDDINGTON D L，KASHKOULI A，BUCHMEIER N A.Growth of Mycobacterium tuberculosis in a Defined Medium Is Very Restricted by Acid pH and Mg ²⁺ Levels［J］.Infection & Immunity，2000，68（8）:4518.

［34］ALNIMR A M.Dormancy models for Mycobacterium tuberculosis:A minireview［J］.Brazilian Journal of Microbiology，2015，46（3）:641-647.

［35］HU Y，COATES A R，MITCHISON D A.Sterilising action of pyrazinamide in models of dormant and rifampicin-tolerant Mycobacterium tuberculosis［J］.International Journal of Tuberculosis & Lung Disease，2006，10（3）:317.

［36］LIM A，ELEUTERIO M，HUTTER B，et al.Oxygen depletion-induced dormancy in Mycobacterium bovis BCG［J］.Journal of Bacteriology，1999，181（7）:2252-2256. yJ/DnskMS42xbdvgBG6pOLwfOziKpGSQRuh4UPYRAFxqZgUSH1ccpGOr3fitn6QQ