参考文献

［1］卓安·科埃尼格·考斯特．老年痴呆症的人性化康护理念和实践：老年痴呆症的希望之光[M]．于恩彦，译．浙江：浙江大学出版社，2015．

［2］于恩彦，朱俊鹏，谭云飞，等．阿尔茨海默病的早期全面系统长期防治新观念[J]．中华老年医学杂志，2018，37 (11)：1299-1304．

［3］World Health Organization (WHO). Report of health planning workshop [R/OL].(1998-3-2)[2020-12-20]. http://afghandata. org: 8080/xmlui/handle/azu/4377.

［4］World Health Organization (WHO), United Nations Environment Programme (UNEP). Children’s environmental health international initiatives [R/OL].[2020-12-21]. http://afghandata. org: 8080/xmlui/handle/123456789/22444.

［5］AKSOYDAN E, AYTAR A, BLAZEVICIENE A, et al. Is training for informal caregivers and their older persons helpful?A systematic review [J]. Archives of Gerontology and Geriatrics, 2019, 83: 66-74.

［6］ALBANESE E, LAUNER L J, EGGER M, et al. Body mass index in midlife and dementia: Systematic review and meta-regression analysis of 589, 649 men and women followed in longitudinal studies [J]. Alzheimer’s & Dementia: Diagnosis, Assessment &Disease Monitoring, 2017, 8: 165-178.

［7］ALSHARIF A A, WEI L, MA T, et al. Prevalence and incidence of dementia in people with diabetes mellitus [J]. Journal of Alzheimer’s Disease, 2020, 75 (2): 607-615.

［8］ANATÜRK M, SURI S, ZSOLDOS E, et al. Associations between longitudinal trajectories of cognitive and social activities and brain health in old age [J]. JAMA network open, 2020, 3 (8): e2013793.

［9］于恩彦．实用老年精神医学[M]．浙江：浙江大学出版社，2013．

［10］AREOSA SASTRE A, VERNOOIJ R W, GONZÁLEZ-COLAÇO HARMAND M, et al. Effect of the treatment of type 2 diabetes mellitus on the development of cognitive impairment and dementia [J]. The Cochrane Database of Systematic Reviews, 2017, 6 (6):CD003804.

［11］ATRI A. The Alzheimer’s disease clinical spectrum [J]. Medical Clinics of North America,2019, 103 (2): 263-293.

［12］BARHA C K, DAVIS J C, FALCK R S, et al. Sex differences in exercise efficacy to improve cognition: A systematic review and meta-analysis of randomized controlled trials in older humans [J]. Frontiers in Neuroendocrinology, 2017, 46: 71-85.

［13］BARRIOS P G, GONZÁLEZ R P, HANNA S M, et al. Priority of treatment outcomes for caregivers and patients with mild cognitive impairment: Preliminary analyses [J]. Neurology and Therapy, 2016, 5 (2): 183-192.

［14］BARTELS C, WAGNER M, WOLFSGRUBER S, et al. Impact of SSRI therapy on risk of conversion from mild cognitive impairment to Alzheimer’s dementia in individuals with previous depression [J]. American Journal of Psychiatry, 2018, 175 (3): 232-241.

［15］BAUNE B T, BRIGNONE M, LARSEN K G. A network meta-analysis comparing effects of various antidepressant classes on the digit symbol substitution test (DSST) as a measure of cognitive dysfunction in patients with major depressive disorder [J]. The International Journal of Neuropsychopharmacology, 2018, 21 (2): 97-107.

［16］BLIESZNER R, ROBERTO K A. Care partner responses to the onset of mild cognitive impairment [J]. The Gerontologist, 2010, 50 (1): 11-22.

［17］BOLLER B, BELLEVILLE S. Cognitive intervention in older adults with mild cognitive impairment [J/OL].(2018-12-20)[2020-12-21]. https://doi. org/10. 1093/acrefore/9780190236557. 013. 446.

［18］BRUCE D G, DAVIS W A, STARKSTEIN S E, et al. Mid-life predictors of cognitive impairment and dementia in type 2 diabetes mellitus: The fremantle diabetes study [J]. Journal of Alzheimer’s Disease, 2014, 42 (3): S63-S70.

［19］CHENG S T, CHAN W C, LAM L C W. Long-term outcomes of the benefit-finding group intervention for Alzheimer family caregivers: A cluster-randomized double-blind controlled trial [J]. The American Journal of Geriatric Psychiatry, 2019, 27 (9): 984-994.

［20］CHIU H L, CHU H, TSAI J C, et al. The effect of cognitive-based training for the healthy older people: A meta-analysis of randomized controlled trials [J]. PloS One, 2017, 12 (5): e0176742.

［21］D’CUNHA N M, GEORGOUSOPOULOU E N, DADIGAMUWAGE L, et al. Effect of long-term nutraceutical and dietary supplement use on cognition in the elderly: A 10-year systematic review of randomised controlled trials [J]. British Journal of Nutrition, 2018, 119 (3): 280-298.

［22］DAFSARI F S, JESSEN F. Depression-an underrecognized target for prevention of dementia in Alzheimer’s disease [J]. Translational psychiatry, 2020, 10 (1): 160.

［23］DAVIS K A S, BISHARA D, PERERA G, et al. Benefits and harms of statins in people with dementia: A systematic review and meta‐analysis [J]. Journal of the American Geriatrics Society, 2020, 68 (3): 650-658.

［24］DE SAÁ GUERRA Y, SARMIENTO MONTESDEOCA S, GARCÍA MANSO J M, et al. Exercise and Alzheimer’s: The body as a whole [J]. Revista Andaluza de Medicina del Deporte, 2017, 10 (3): 120-124.

［25］DE SOUTO BARRETO P, DEMOUGEOT L, VELLAS B, et al. Exercise training for preventing dementia, mild cognitive impairment, and clinically meaningful cognitive decline: A systematic review and meta-analysis [J]. The Journals of Gerontology: Series A, 2017, 73 (11): 1504-1511.

［26］GALLAWAY P J, MIYAKE H, BUCHOWSKI M S, et al. Physical activity: A viable way to reduce the risks of mild cognitive impairment, Alzheimer’s disease, and vascular dementia in older adults [J]. Brain Sciences, 2017, 7 (2): 22.

［27］GEIFMAN N, BRINTON R D, KENNEDY R E, et al. Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease [J]. Alzheimer’s research &Therapy, 2017, 9 (1): 10.

［28］HERSI M, IRVINE B, GUPTA P, et al. Risk factors associated with the onset and progression of Alzheimer’s disease: A systematic review of the evidence [J]. NeuroToxi-Cology, 2017, 61: 143-187.

［29］HILL E, GOODWILL A M, GORELIK A, et al. Diet and biomarkers of Alzheimer’s disease: A systematic review and meta-analysis [J]. Neurobiology of Aging, 2019,76: 45-52.

［30］HOFMAN A, OTT A, BRETELER M M B, et al. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer’s disease in the Rotterdam Study [J]. The Lancet,1997, 349 (9046): 151-154.

［31］HUNTER S W, DIVINE A, MADOU E, et al. Executive function as a mediating factor between visual acuity and postural stability in cognitively healthy adults and adults with Alzheimer’s dementia [J]. Archives of Gerontology and Geriatrics, 2020, 89: 104078.

［32］IADECOLA C. Revisiting atherosclerosis and dementia [J]. Nature Neuroscience, 2020, 23 (6): 691-692.

［33］JIA R-X, LIANG J-H, XU Y, et al. Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: A meta-analysis [J]. BMC geriatrics, 2019, 19 (1): 181.

［34］KARSSEMEIJER E G A, AARONSON J A, BOSSERS W J, et al. Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis [J]. Ageing Research Reviews, 2017, 40: 75-83.

［35］KRESSIG R W. Demenz vom Alzheimer-typ: Nicht-medikamentöse und medikamentöse therapie [J]. Therapeutische Umschau, 2015, 72 (4): 233-238.

［36］KUIPER J S, ZUIDERSMA M, OUDE VOSHAAR R C, et al. Social relationships and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies [J]. Ageing Research Reviews, 2015, 22: 39-57.

［37］LANGA K M, LEVINE D A. The diagnosis and management of mild cognitive impairment: A clinical review [J]. JAMA, 2014, 312 (23): 2551-2561.

［38］LICHER S, AHMAD S, KARAMUJIĆ-ČOMIĆH, et al. Genetic predisposition, modif iable-risk-factor profile and long-term dementia risk in the general population [J]. Nature Medicine, 2019, 25 (9): 1364-1369.

［39］LIM R H, SHARMEEN T. Medicines management issues in dementia and coping strategies used by people living with dementia and family carers: A systematic review [J]. International Journal of Geriatric Psychiatry, 2018, 33 (12): 1562-1581.

［40］LU Y, SUGAWARA Y, ZHANG S, et al. Smoking cessation and incident dementia in elderly Japanese: The Ohsaki Cohort 2006 Study [J]. European Journal of Epidemiology, 2020, 35 (9): 851-860.

［41］MATYAS N, KESER ASCHENBERGER F, WAGNER G, et al. Continuing education for the prevention of mild cognitive impairment and Alzheimer’stype dementia: A systematic review and overview of systematic reviews [J]. BMJ open, 2019, 9 (7): e027719.

［42］MIJAJLOVIĆM D, PAVLOVIĆA, BRAININ M, et al. Post-stroke dementia-a comprehensive review [J]. BMC medicine, 2017, 15 (1): 11.

［43］MOUSTAFA A A, TINDLE R, ALASHWAL H, et al. A longitudinal study using latent curve models of groups with mild cognitive impairment and Alzheimer’s disease [J]. Journal of Neuroscience Methods, 2021, 350: 109040.

［44］NAKANO M, KUBOTA K, HASHIZUME S, et al. An enriched environment prevents cognitive impairment in an Alzheimer’s disease model by enhancing the secretion of exosomal MicroRNA-146a from the choroid plexus [J]. Brain, Behavior,& Immunity-Health, 2020, 9: 100149.

［45］NISHIGUCHI S, YAMADA M, TANIGAWA T, et al. A 12-week physical and cognitive exercise program can improve cognitive function and neural efficiency in communitydwelling older adults: A randomized controlled trial [J]. Journal of the American Geriatrics Society, 2015, 63 (7): 1355-1363.

［46］NORTHEY J M, CHERBUIN N, PUMPA K L, et al. Exercise interventions for cognitive function in adults older than 50: A systematic review with meta-analysis [J]. British Journal of Sports Medicine, 2017, 52 (3): 154-160.

［47］PARSONS C, MURAD M H, ANDERSEN S, et al. The effect of antihypertensive treatment on the incidence of stroke and cognitive decline in the elderly: A meta-analysis [J]. Future Cardiology, 2016, 12 (2): 237-248.

［48］PETERSSON S, PHILIPPOU E. The effects of mediterranean diet on cognitive function and dementia: Systematic review of the evidence [J]. Clinical Nutrition ESPEN, 2016, 13: e67.

［49］PETERSSON S D, PHILIPPOU E. Mediterranean diet, cognitive function,and dementia: A systematic review of the evidence [J]. Advances in Nutrition(Bethesda, Md.), 2016, 7 (5): 889-904.

［50］PLEASANT M, MOLINARI V, DOBBS D, et al. Effectiveness of online dementia caregivers training programs: A systematic review [J]. Geriatric Nursing, 2020, 41 (6):921-935.

［51］RADD-VAGENAS S, DUFFY S L, NAISMITH S L, et al. Effect of the mediterranean diet on cognition and brain morphology and function: A systematic review of randomized controlled trials [J]. The American Journal of Clinical Nutrition, 2018, 107 (3): 389-404.

［52］RUTHERFORD B R, BREWSTER K, GOLUB J S, et al. Sensation and psychiatry: Linking age-related hearing loss to late-life depression and cognitive decline [J]. The American journal of psychiatry, 2018, 175 (3): 215-224.

［53］SHERMAN D S, MAUSER J, NUNO M, et al. The efficacy of cognitive intervention in mild cognitive impairment (MCI): A meta-analysis of outcomes on neuropsychological measures [J]. Neuropsychology Review, 2017, 27 (4): 440-484.

［54］SHI L, CHEN S-J, MA M-Y, et al. Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis [J]. Sleep Medicine Reviews, 2018, 40: 4-16.

［55］SOLFRIZZI V, AGOSTI P, LOZUPONE M, et al. Nutritional intervention as a preventive approach for cognitive-related outcomes in cognitively healthy older adults: A systematic review [J]. Journal of Alzheimer’s Disease, 2018, 64 (s1): S229-S254.

［56］SONG D, YU DSF, LI PWC, et al. The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: A systematic review and meta-analysis [J]. International Journal of Nursing Studies, 2018, 79: 155-164.

［57］TOCHEL C, SMITH M, BALDWIN H, et al. What outcomes are important to patients with mild cognitive impairment or Alzheimer’s disease, their caregivers, and healthcare professionals?A systematic review [J]. Alzheimer’s & Dementia: Diagnosis,Assessment & Disease Monitoring, 2019, 11: 231-247.

［58］TURANA Y, TENGKAWAN J, CHIA Y C, et al. Hypertension and dementia: A comprehensive review from the hope Asia network [J]. The Journal of Clinical Hypertension, 2019, 21 (8): 1091-1098.

［59］VASEFI M, GHABOOLIAN-ZARE E, ABEDELWAHAB H, et al. Environmental toxins and Alzheimer’s disease progression [J]. Neurochemistry International, 2020, 141: 104852.

［60］VERONESE N, FACCHINI S, STUBBS B, et al. Weight loss is associated with improvements in cognitive function among overweight and obese people: A systematic review and meta-analysis [J]. Neuroscience & Biobehavioral Reviews, 2017, 72: 87-94.

［61］WEISS J, FREEMAN M, LOW A, et al. Benefits and harms of intensive blood pressure treatment in adults aged 60 years or older [J]. Annals of Internal Medicine, 2017, 166 (6): 419.

［62］WHITSON H E, CRONIN-GOLOMB A, CRUICKSHANKS K J, et al. American geriatrics society and national institute on aging bench-to-bedside conference: Sensory impairment and cognitive decline in older adults [J]. Journal of the American Geriatrics Society, 2018, 66 (11): 2052-2058.

［63］WIEGMANN C, MICK I, BRANDL E J, et al. Alcohol and dementia-what is the link？A systematic review [J]. Neuropsychiatric Disease and Treatment, 2020, 16: 87-99.

［64］WORTMANN M. P4-151: World Alzheimer report 2014: Dementia and risk reduction [J]. Alzheimer’s & Dementia, 2015, 1 (1): P837-P837.

［65］XU W, TAN L, WANG H-F, et al. Meta-analysis of modifiable risk factors for Alzheimer’s disease [J]. Journal of Neurology, Neurosurgery & Psychiatry, 2015, 86 (12): 310548.

［66］ZHANG X, TIAN Q, LIU D, et al. Causal association of circulating cholesterol levels with dementia: A mendelian randomization meta-analysis [J]. Translational psychiatry, 2020, 10 (1): 145. 8DyMe8rTTCDmL3pYOI7HUxp4XvZ0UJbYcbH/myxz1NxVkUioNFzvsb4+cukybrBa