参考文献

BIRGITG，BROSENS J J，2014.Cyclic decidualization of the human endometrium in reproductive health and failure.Endocr Rev，35（6）：851-905.

BLACK S，KADYROV M，KAUFMANN P，et al.，2004.Syncytial fusion of human trophoblast depends on caspase 8.Cell Death Differ，11（1）：90-98.

BULMER JN，INNES B A，LEVEY J，et al.，2012.The role of vascular smooth muscle cell apoptosis and migration during uterine spiral artery remodeling in normal human pregnancy.FASEB J，26（7）：2975-2985.

BURTON G J，CHARNOCK-JONES D S，JAUNIAUX E，2006.Working with oxygen and oxidative stress in vitro.Methods Mol Med，122：413-425.

CHA J，SUN X，DEY SK，2012.Mechanisms of implantation：strategies for successful pregnancy.Nat Med，18（12）：1754-1767.

CHEN C P，CHEN C Y，YANG Y C，et al.，2004.Decreased placental GCM1（glial cellsmissing）gene expression in pre-eclampsia.Placenta，25（5）：413-421.

CHEN C P，CHEN L F，YANG SR，et al.，2008.Functional characterization of the human placental fusogenic membrane protein syncytin 2.Biol Reprod，79（5）：815-823.

CHEN C P，WANG K G，CHEN C Y，et al.，2006.Altered placental syncytin and its receptor ASCT2 expression in placental development and pre-eclampsia.BJOG，113（2）：152-158.

COCKBURN K，ROSSANT J，2010.Making the blastocyst：lessons from themouse.JClin Invest，120（4）：995-1003.

DALTON P，CHRISTIAN H C，REDMAN CW，et al.，2007.Membrane trafficking of CD98 and its ligand galectin 3 in BeWo cells—implication for p lacental cell fusion.FEBS J，274（11）：2715-2727.

DAOUD G，AMYOTM，RASSART E，et al.，2005.ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta.JPhysiol，566（Pt 2）：409-423.

DEGLINCERTI A，CROFTG F，PIETILA L N，et al.，2016.Self-organization of the in vitro attached human embryo.Nature，533（7602）：251-254.

FRENDO J L，CRONIER L，BERTIN G，et al.，2003a.Involvement of connexin 43 in human trophoblast cell fusion and differentiation.JCell Sci，116（Pt 16）：3413-3421.

FRENDO JL，OLIVIER D，CHEYNET V，et al.，2003b.Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation.Mol Cell Biol，23（10）：3566-3574.

GENBACEV O，ZHOU Y，Ludlow JW，et al.，1997.Regulation of human placental development by oxygen tension.Science，277（5332）：1669-1672.

HERTIG A T，ROCK J，ADAMS E C，1956.A description of 34 human ova within the first 17 days of development.Am J Anat，98（3）：435-493.

HUOVILA A P，ALMEIDA E A，WHITE JM，1996.ADAMs and cell fusion.Curr Opin Cell Biol，8（5）：692-699.

HUPPERTZ B，MEIRIH，GIZURARSON S，et al.，2013.Placental protein 13（PP13）：a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia.Hum Reprod Update，19（4）：391-405.

JANSSON T，2001.Amino acid transporters in the human placenta.Pediatr Res，49（2）：141-147.

JIL，BRKIC J，WANG Y L，et al.，2013.Placental trophoblast cell differentiation：physiological regulation and pathological relevance to preeclampsia.Mol Aspects Med，34（5）：981-1023.

KAR M，GHOSH D，SENGUPTA J，2007.Histochemical and morphological examination of proliferation and apoptosis in human first trimester villous trophoblast.Hum Reprod，22（11）：2814-2823.

KNERR I，SCHUBERT SW，WICH C，et al.，2005.Stimulation of GCMa and syncytin via cAMPmediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions.FEBS Lett，579（18）：3991-3998.

KUDO Y，BOYD C A R，2002.Human placental amino acid transporter genes：expression and function.Reproduction，124（5）：593-600.

KUDO Y，BOYD C A R，2004.RNA interference-induced reduction in CD98 expression suppresses cell fusion during syncytialization of human placental BeWo cells.Febs Letters，577（3）：473-477.

KUDO Y，BOYD C A R，MILLO J，et al.，2003.Manipulation of CD98 expression affectsboth trophoblast cell fusion and amino acid transportactivity during syncytialization of human p lacental BeWo cells.JPhysiol，550（Pt 1）：3-9.

LIN C，LIN M，CHEN H，2005.Biochemical characterization of the human placental transcription factor GCMa/1.Biochem Cell Biol，83（2）：188-195.

MIS，LEE X，LIX P，et al.，2000.Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis.Nature，403（6771）：785-789.

MOFFETT-KING A，2002.Natural killer cells and pregnancy.NatRev Immunol，2（9）：656-663.

PLANT TM，ZELEZNIK A J，et al.，2015.knobil and neill’s physiology of reproduction.4th ed.Philadelphia：Elsevier Inc.

REDMAN CW G，LINTON E A，SARGENT IL，2007.Circulatingmicroparticles and immunomodulation in pregnancy and preeclampsia.Placenta，28（8-9）：A6.

RENARDM，VARELA P F，LETZELTER C，et al.，2005.Crystal structure ofa pivotal domain of human syncytin-2，A 40million years old endogenous retrovirus fusogenic envelope gene captured by primates.JMol Biol，352（5）：1029-1034.

ROBERTSJM，GAMMILL H S，2005.Preeclampsia：recent insights.Hypertension，46（6）：1243-1249.

SHAHBAZIM N，JEDRUSIK A，VUORISTO S，et al.，2016.Self-organization of the human embryo in the absence of maternal tissues.Nat Cell Biol，18（6）：700-708.

SMITH SD，DUNK C E，APLIN JD，et al.，2009.Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy.Am JPathol，174（5）：1959-1971.

STONE A L，KROEGER M，SANG Q X，1999.Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins（review）.JProtein Chem，18（4）：447-465.

VARGAS A，MOREAU J，LANDRY S，et al.，2009.Syncytin-2 plays an important role in the fusion of human trophoblast cells.JMol Biol，392（2）：301-318.

WANG H，DEY S K，2006.Roadmap to embryo imp lantation：clues from mousemodels.Nat Rev Genet，7（3）：185-199.

WHITE L，DHARMARAJAN A，CHARLES A，2007.Caspase-14：a new player in cytotrophoblast differentiation.Reprod Biomed Online，14（3）：300-307.

ZHANG S，LINH Y，KONG SB，et al.，2013.Physiological andmolecular determinants of embryo implantation.Mol Aspects Med，34（5）：939-980. dZJhmuQneD0THqy+7FLl5HxrWTU5jpQqdW02+PQi7Bm9mJlX6obT10BCmUH5FUHm