[1]GOTTLIEB M,LONG B,KOYFMAN A.The evaluation and management of Rocky Mountain spotted fever in the emergency department:a review of the literature.J Emerg Med,2018,55(1):42-50.
[2]SINGER KE,COLLINS CE,FLAHIVE JM,et al.Outpatient beta-blockers and survival from sepsis:results from a national cohort of medicare beneficiaries.Am J Surg,2017,214(4):577-582.
[3]刘保池,蔡端,朱同玉.特殊感染外科新理念与新技术.上海:上海科技教育出版社,2017.
[4]WALKEY AJ,LAGU T,LINDENAUER PK.Trends in sepsis and infection sources in the United States.A population-based study.Ann Am ThoracSoc,2015,12(2):216-220.
[5]FLEISCHMANN C,SCHERAG A,ADHIKARI NK,et al.Assessment of global incidence and mortality of hospital-treated sepsis.Current estimates and limitations.Am J Respir Crit Care Med,2016,193(3):259-272.
[6]MCGARRITY S,ANUFORO Ó,HALLDÓRSSON H,et al.Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification.Sci Rep,2018,8(1):6811.
[7]LIU S,WU X,LOPEZ AD,et al.An integrated national mortality surveillance system for death registration and mortality surveillance,China.Bull World Health Organ,2016,94(1):46-57.
[8]刘保池,蔡端.特殊感染外科学.上海:上海科技教育出版社,2014.
[9]RAUCH PJ,CHUDNOVSKIY A,ROBBINS CS,et al.Innate response activator B cells protect against microbial sepsis.Science,2012,335(6068):597-601.
[10]WYNN TA.Type 2 cytokines:mechanisms and therapeutic strategies.Nat Rev Immunol,2015,15(5):271-282.
[11]储以微.医学免疫学.上海:复旦大学出版社,2015.
[12]BONE RC,BALK RA,CERRA FB,et al.Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.The ACCP/SCCM Consensus Conference Committee.American College of Chest Physicians /Society of Critical Care Medicine.Chest,1992,101(6):1644-1655.
[13]SINGER M,DEUTSCHMAN CS,SEYMOUR CW,et al.The third international consensus definition for sepsis and septic shock(sepsis-3).JAMA,2016,315(8):801-810.
[14]MARTIN GS,MANNINO DM,EATON S,et al.The epidemiology of sepsis in the United States from 1979 through 2000.N Engl J Med,2003,348(16):1546-1554.
[15]PARK DW,ZMIJEWSKI JW.Mitochondrial dysfunction and immune cell metabolism in sepsis.Infect Chemother,2017,49(1):10-21.
[16]CHENG SC,SCICLUNA BP,ARTS RJ,et al.Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis.Nat Immunol,2016,17(4):406-413.
[17]HAN CY,SONG Q,REN YC,et al.Dose-response association of operative time and surgical site infection in neurosurgery patients:a systematic review and meta-analysis.Am J Infect Control,2019,47:1393-1396.
[18]胡逢静,蔡玲,杨亚红,等.神经外科医院感染现状及其风险评估研究进展.中华医院感染学杂志,2019,29(8):1267-1271.
[19]BENTZER P,FJELL C,WALLEY KR,et al.Plasma cytokine levels predict response to corticosteroids in septic shock.Intensive Care Med,2016,42(12):1970-1979.
[20]汪复.感染性疾病与抗微生物治疗.3版.上海:复旦大学出版社,2008.
[21]ARULKUMARAN N,POLLEN S,GRECO E,et al.Renal tubular cell mitochondrial dysfunction occurs despite preserved renal oxygen delivery in experimental septic acute kidney injury.Crit Care Med,2018,46(4):e318-e325.
[22]PAN P,WANG X,LIU D.The potential mechanism of mitochondrial dysfunction in septic cardiomyopathy.J Int Med Res,2018,46(6):2157-2169.
[23]BURGDORFF AM,BUCHER M,SCHUMANN J.Vasoplegia in patients with sepsis and septic shock:pathways and mechanisms.J Int Med Res,2018,46(4):1303-1310.
[24]顾觉奋.抗生素.上海:山海科学技术出版社,2001.
[25]HAN RT,KIM S,CHOI K,et al.Asthma-like airway inflammation and responses in a rat model of atopic dermatitis induced by neonatal capsaicin treatment.J Asthma Allergy,2017,10:181-189.
[26]PARANDE-SHIRVAN S,EBRAHIMBY A,DOUSTY A,et al.Somatic extracts of Marshallagia marshalli down regulate the Th2 associated immune responses in ovalbumininduced airway inflammation in BALB/c mice.Parasit Vectors,2017,10(1):233.
[27]安兵,胡丽华,游波,等.临床外科危急重症治疗学.天津:天津科学技术出版社,2011.
[28]BUI TT,PIAO CH,SONG CH,et al.Bupleurum chinense extract ameliorates an OVA-induced murine allergic asthma through the reduction of the Th2 and Th17 cytokines production by inactivation of NFκB pathway.Biomed Pharmacother,2017,91:1085-1095.
[29]WENG L,ZENG XY,YIN P,et al.Sepsis related mortality in China:a descriptive analysis.Intensive Care Med,2018,44(7):1071-1080.
[30]江正辉,刘兴才,陈微.神经系统感染诊断与治疗.上海:上海第二军医大学出版社,2006.
[31]TAEB AM,HOOPER MH,MARIK PE.Sepsis:current definition,pathophysiology,diagnosis,and management.Nutr Clin Pract,2017,32(3):296-308.
[32]TAHAMTAN A,TEYMOORI-RAD M,NAKSTAD B,et al.Anti-inflammatory microRNAs and their potential for inflammatory diseases treatment.Front Immunol,2018,9:1377.
[33]孙田杰.外科护理学.2版.上海:上海科学技术出版社,2016.
[34]LUZINA IG,KEEGAN AD,HELLER NM,et al.Regulation of inflammation by interleukin-4:a review of “alternatives”.J Leukoc Biol,2012,92(4):753-764.
[35]WEBER GF,CHOUSTERMAN BG,HE S,et al.Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.Science,2015,347(6227):1260-1265.
[36]塞默尔·I.斯克华兹.外科原则.彭忠民,译.江西:江西科学技术出版社,2002.
[37]RIZZO AN,DUDEK SM.Endothelial glycocalyx repair:building a wall to protect the lung during sepsis.Am J Respir Cell Mol Biol,2017,56(6):687-688.
[38]CHEN J,XUAN J,GU YT,et al.Celastrol reduces IL-1β induced matrix catabolism,oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo.Biomed Pharmacother,2017,91:208-219.
[39]陈涛,丁岚.脓毒症炎症调控的研究进展.实用临床医学,2015,16(6):104-107.
[40]USHIKI T,HUNTINGTON ND,GLASER SP,et al.Rapid inflammation in mice lacking both SOCS1 and SOCS3 in hematopoietic cells.PLoS One,2016,11(9):e0162111.
[41]BLUMENTAL-PERRY A,BONFIELD TL.Editorial:modulation of HMGB1 holds promise for managing sepsis immune paralysis.J Leukoc Biol,2017,101(6):1273-1275.
[42]TACCONE FS,SU F,PIERRAKOS C,et al.Cerebral microcirculation is impaired during sepsis:an experimental study.Crit Care,2010,14(4):R140.
[43]TACCONE FS,CASTANARES-ZAPATERO D,PERES-BOTA D,et al.Cerebral autoregulation is influenced by carbon dioxide levels in patients with septic shock.Neurocrit Care,2010,12(1):35-42.
[44]MORANDI A,ROGERS BP,GUNTHER ML,et al.The relationship between delirium duration,white matter integrity,and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging:the VISIONS prospective cohort magnetic resonance imaging study.Crit.Care Med,2012,40(7):2182-2189.
[45]LUITSE MJ,VAN ASCH CJ,KLIJN CJ.Deep coma and diffuse white matter abnormalities caused by sepsis-associated encephalopathy.Lancet,2013,381(9884):2222.
[46]GRIFFIN WS.Neuroinflammatory cytokine signaling and Alzheimer's disease.N Eng J Med,2013,368:770-771.
[47]MARTIN GS,MANNINO DM,EATON S,et al.The epidemiology of sepsis in the United States from 1979 through 2000.N Engl J Med,2003,348(16):1546-1554.
[48]WALKEY AJ,LAGU T,LINDENAUER PK.Trends in sepsis and infection sources in the United States.A population-based study.Ann Am Thorac Soc,2015,12(2):216-220.
[49]RACHEL POOL,HERNANDO GOMEZ,JOHN A KELLUM.Mechanisms of Organ Dysfunction in Sepsis.Crit Care Clin.2018 Jan;34(1):63-80.
[50]LANGENBERG C,BELLOMO R,MAY C,et al.Renal blood flow in sepsis.Crit Care,2005,9:363-374.
[51]TAKASU O,GAUT JP,WATANABE E,et al.Mechanisms of cardiac and renal dysfunction in patients dying of sepsis.Am J of Respir Crit Care Med,2013,187:509.
[52]MATEJOVICM,VALESOVA L,BENES J,et al.Molecular differences in susceptibility of the kidney to sepsis-induced kidney injury.BMC Nephrol,2017,18:183.
[53]VILANDER LM,KAUNISTO MA,VAARA ST,et al.Geneticvariants in SERPINA4 and SERPINA5,but not BCL2 and SIK3 are associated with acute kidney injury in critically ill shock.Crit Care,2017,21:47.
[54]FENG D,WANG Y,LIU Y,et al.DC-SIGN recats with TLR4 and regulates inflammatory cytokine expression via NF-κB activation in renal tubular epithelial cells during acute renal injury.Clinical & Experimental Immunology,2017,191(1):107-115.
[55]任延波,张彧.脓毒血症大鼠肾脏细胞凋亡变化.内科急危重症杂志,2007,13:28.
[56]NEVIERE R,FAUVEL H,CHOPIN C,et al.Caspase inhabition prevents car-diac dysfunction and heart apoptosis in a rat model of sepsis.Am J Respir Crit Care Med,2001,163(1):218-225.
[57]MENG L,LI L,LU S,et al.The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediates TLR4/NF-B and PDK/Akt/mTOR pathway.Molrcular Immunology,2017,94:7-17.
[58]LAI JL,LIU YH,LIU C,et al.Indirubin Inhibits LPS-induced inflammation via,TLR4 Abrogation Mediated MAPK Signaling Pathway.Inflammation,2017,40(1):1-12.
[59]HOLTHOFF JH,WANG Z,SEELY KA,et al.Resveratrol improves renal microcirculation,protects the tubular epithelium,and prolongs survival in a mouse model of sepsis-induced acute kidney injury.Kidney International,2012,81(4):370-378.
[60]CELES MR,PRADO CM,ROSSI MA.Sepsis:going to the heart of the matter.Pathobiology,2013,80(2):70-86.
[61]HASSOUN SM,MARECHAL X,MONTAIGNE D,et al.Prevention of endotoxininduced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction.Crit Care Med,2008,36(9):2590-2596.
[62]TSAO N.,HSU H.P.,WU C.M.,et al.Tumour necrosis factor-α causes an increase in blood-brain barrier permeability during sepsis.J.Med.Microbiol.2001,50:812-821.
[63]IRWAN Y.Y.Quantitative analysis of cytokine-induced vascular toxicity and vascular leak in the mouse brain.J.Immunol.Methods 2009,349:45-55.
[64]SHARSHAR T,GRAY F,LORIN DE LA GRANDMAISON G,et al.Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock.Lancet 2003,362:1799-1805.
[65]JENKINSON M D,SMITH TREVOR S,BRODBELT ANDREW R,et al.Apparent diffusion coefficients in oligodendroglial lumors characterized by genotype.J Magn Reson Imaging,2007,26:1405-1412.
[66]JENKINSON M D,PLESSIS D G D,SMITH T S,et al.Cellularity and apparent diffusion coefficient in oligodendroglial tumours characterized by genotype.J Neurooncol,2010,96(3):385-392.
[67]YAMASHITA Y.,KUMABE T.,HIGANO S.,et al.Minimum apparent diffusion coefficient is significantly correlated with cellularity in medulloblastomas.Neurol.Res.2009,31:940-946.
[68]BOZZA F A,GARTEISER P,OLIVEIRA M F,et al.Sepsis-associated encephalopathy:a magnetic resonance imaging and spectroscopy study.Journal of Cerebral Blood Flow &Metabolism,2010,30(2):440-448.
[69]SEMMLER A,WIDMANN C N,OKULLA T,et al.Persistent cognitive impairment,hippocampal atrophy and EEG changes in sepsis survivors.Journal of Neurology Neurosurgery & Psychiatry,2013,84:62-69.
[70]HOTCHKISS R S,LONG R C,HALL J R,et al.An in vivo examination of rat brain during sepsis with 31P-NMR spectroscopy.Am J Physiol,1989,257(6):1055-1061.
[71]SPRUNG C L,CERRA F B,FREUND H R,et al.Amino acid alterations and encephalopathy in the sepsis syndrome.Critical Care Medicine,1991,19(6):753-757.
[72]KADOI Y.,SAITO S.An alteration in the gamma-aminobutyric acid receptor system in experimentally induced septic shock in rats.Crit.Care Med.1996,24,298-305
[73]VAN DEN BOOGAARD M,KOX M,QUINN KL,et al.Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction;indications for different pathways governing delirium in inflamed and noninflamed patients.Crit Care 2011;15:R297.
[74]RENNO T,KRAKOWSKI M,PICCIRILLO C,et al.TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis.Regulation by Th1 cytokines.J Immunol 1995;154:944-953.
[75]BOOMER JS,TO K,CHANG KC,et al.Immunosuppression in patients who die of sepsis and multiple organ failure.JAMA 2011;306:2594-2605.
[76]HOTCHKISS RS,COOPERSMITH CM,MCDUNN JE,et al.The sepsis seesaw:Tilting toward immunosuppression.Nature Med 2009;15:496-497.Back to cited text no.
[77]CUNNEEN J,CARTWRIGHT M.The puzzle of sepsis:Fitting the pieces of the inflammatory response with treatment.AACN Clin Issues 2004;15:18-44.
[78]POCH B,GANSAUGE F,RAU B,et al.The role of polymorphonuclear leukocytes and oxygen-derived free radicals in experimental acute pancreatitis:Mediators of local destruction and activators of inflammation.FEBS Lett 1999;461:268-272.
[79]FLIERL M A,STAHEL P F,RITTIRSCH D,et al.Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis[J].Critical Care,2009,13(1):1-9.