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［2］DUFF JP，TOPJIAN A，BERGM D，etal.2018American Heart Association Focused Update on Pediatric Advanced LifeSupport：An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care［J］.Circulation，2018，138（23）：e731-e739.
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［4］POWERSW J，RABINSTEIN A A，ACKERSON T，et al.2018Guidelines for the Early Management of PatientsWith AcuteIschemic Stroke：A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association［J］.Stroke，2018，49（3）：e46-e110.
［5］YENARIM A，HAN H S.Neuroprotective mechanisms of hypothermia in brain ischaemia［J］.Nat RevNeurosci，2012，13（4）：267-278.
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［7］MELMED K R，LYDEN P D.Meta-Analysisof Pre-Clinical Trials of Therapeutic Hypothermia for Intracerebral Hemorrhage［J］.Ther Hypothermia Temp Manag，2017，7（3）：141-146.
［8］FISCHERM，SCHIEFECKER A，Lackner P，et al.Targeted Temperature Management in Spontaneous Intracerebral Hemorrhage：A Systematic Review［J］.Curr Drug Targets，2017，18（12）：1430-1440.
［9］HYPOTHERMIA AFTER CARDIAC ARRESTSTUDY GROUP.Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest［J］.The New England journal ofmedicine，2002，346（8）：549-556.
［10］NOLAN J P，MORLEY P T，HOEK T L V，et al.Therapeutic hypothermia after cardiac arrest：an advisory statement by theadvanced life support task force of the International Liaison Committee on Resuscitation［J］.Circulation，2003，108（1）：118-121.
［11］PEBERDY M A，CALLAWAY C W，NEUMAR RW，et al.Part 9：post-cardiac arrest care：2010American HeartAssociation Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care［J］.Circulation，2010，122（18 Suppl 3）：S768-786.
［12］NIELSEN N，WETTERSLEV J，CRONBERG T，et al.Targeted temperature managementat33℃versus36℃after cardiac arrest［J］.The New England journal ofmedicine，2013，369（23）：2197-2206.
［13］THORESENM，TOOLEY J，LIU X，et al.Time is brain：starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns［J］.Neonatology，2013，104（3）：228-233.
［14］KATTWINKEL J，PERLMAN J M，AZIZ K，et al.Part 15：neonatal resuscitation：2010American Heart AssociationGuidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care［J］.Circulation，2010，122（18 Suppl 3）：S909-919.
［15］WU L，WU D，YANG T，et al.Hypothermic neuroprotection against acute ischemic stroke：The 2019update［J］.JCerebBlood Flow Metab，2020，40（3）：461-481.
［16］KOLLMAR R，STAYKOV D，DORFLER A，et al.Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage［J］.Stroke，2010，41（8）：1684-1689.
［17］CLIFTON G L，VALADKA A，ZYGUN D，et al.Very early hypothermia induction in patientswith severe brain injury（the National Acute Brain Injury Study：Hypothermia II）：a randomised trial［J］.Lancet Neurol，2011，10（2）：131-139.
［18］LEGRIEL S，LEMIALE V，SCHENCK M，et al.Hypothermia for Neuroprotection in Convulsive Status Epilepticus［J］.The New England journal ofmedicine，2016，375（25）：2457-2467.
［19］MOURVILLIERB，TUBACH F，VAN DE BEEK D，et al.Induced hypothermia in severe bacterial meningitis：a randomizedclinical trial［J］.JAMA，2013，310（20）：2174-2183.
［20］LIF，GENG X，YIP J，et al.Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood-Brain Barrier Disruption after Ischemic Stroke［J］.Cell transplantation，2019，28（2）：145-156.