参考文献

1.郝伟，于欣.精神病学.7版.北京：人民卫生出版社，2013

2.沈渔邨.精神病学.5版.北京：人民卫生出版社，2009

3.范建华，沈渔邨，周朝凤，等.汉族酒依赖高发家系单胺氧化酶A基因多态性的对照研究.中华精神科杂志，1999，32（3）：160-163

4.Wang J，Carnicella S，Phamluong K，et al.Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum： implications for alcohol drinking behavior.Neurosci 200727：3593-3602

5.Sheela Rani CS，Ticku MK.Comparison of chronic ethanol and chronic intermittent ethanol treatments on the expression of GABA（A）and NMDA receptor subunits.Alcohol 2006，38：89-97

6.Boyce-Rustay JM，Holmes A.Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit.Psychopharmacology，2006，187：455-466

7.Sato Y，Seo N，Kobayashi E.Ethanol-induced hypnotic tolerance is absent in N-methyl-D-aspartate receptor ε1 subunit knockout mice.Anesth Analg，2006，103：117-120

8.Yin HH，Park BS，Adermark L，et al.Ethanol reverses the direction of long-term synaptic plASTicity in the dorsomedial striatum.Eur J Neurosci，2007，25：3226-3232

9.Wang J，Carnicella S，Phamluong K，et al.Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum： implications for alcohol drinking behavior.Neurosci，2007，27：3593-3602

10.Szumlinski KK，Diab ME，Friedman R，et al.Accumbens neurochemical adaptations produced by binge-like alcohol consumption.Psychopharmacology，2007，190（3）：415-431

11.Zuo GC，Yang JY，Hao Y，et al.Ethanol and acetaldehyde induce similar changes in extracellular levels of glutamate，taurine and GABA in rat anterior cingulate cortex.Toxicol Lett，2007，169：253-258

12.Zhu W，Bie B，Pan ZZ.Involvement of non-NMDA glutamate receptors in central amygdala in synaptic actions of ethanol and ethanol-induced reward behavior.Neurosci，2007，27：289-298

13.Bönsch D，Lenz B，Fiszer R，et al.Lowered DNA methyltransferase（DNMT-3b）mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism.Neural Transm，2006，113：1299-1304

14.Bleich S，Lenz B，Ziegenbein M，et al.Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence.Alcohol Clin Exp Res，2006，30：587-591

15.Bardag-Gorce F，French BA，Joyce M，et al.Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels.Exp Mol Pathol，2007，82：197-202

16.Bardag-Gorce F，Oliva J，Dedes J，et al.Chronic ethanol feeding alters hepatocyte memory which is not altered by acute feeding.Alcohol Clin Exp Res，2009，33：684-692

17.Biermann T，Reulbach U，Lenz B，et al.N-methyl-D-aspartate 2b receptor subtype（NR2B）promoter methylation in patients during alcohol withdrawal.J Neural Transm，2009，116：615-622

18.Bleich S，Hillemacher T.Homocysteine，alcoholism and its molecular networks.Pharmacopsychiatry，2009，S102-109

19.Balae S，Marcos M，Szabo G.Emerging role of microRNAs in liver diseases.World J GASTroenterol，2009，15：5633-5640

20.Cowmeadow RB，Krishnan HR，Atkinson NS.The slowpoke gene is necessary for rapid ethanol tolerance in Drosophila.Alcohol Clin Exp Res，2005，29：1777-1786

21.Delcuve GP，RASTegar M，Davie JR.Epigenetic Control J Cell Physiol，2009，219-243

22.Dolganiuc A，Petrasek J，Kodys K，et al.MicroRNA expression profile in Lieber-DeCarli dietinduced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice.Alcohol Clin Exp Res，2009，33：1704-1710

23.Esfandiari F，Medici V，Wong DH，et al.Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse.Hepatology，2010，51（3）：932-941

24.Feng J，Fan G.The role of DNA methylation in the central nervous system and neuropsychiatric disorders.Int Rev Neurobiol，2009，89：67-84

25.Goll MG，Kirpekar F，Maggert KA，et al.Methylation of tRNA Asp by the DNA methyltransferase homolog Dnmt2.Science，2006，311：395-398

26.Grayson DR，Kundakovic M，Sharma RP.Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders？ Mol Pharmacol，2010，77：126-135

27.Hillemacher T，Frieling H，Luber K，et al.Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal.Psychoneuro-endocrinology，2009，34：555-560

28.Hillemacher T，Frieling H，Hartl T，et al.Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving.J Psychiatr Res，2009，43（4）：388-392

29.Haycock PC，Ramsay M.Exposure of mouse embryos to ethanol during preimplantation development： effect on DNA methylation in the h19 imprinting control region.Biol Reprod，2009，81（4）：618-627

30.Haycock PC.Fetal alcohol spectrum disorders： the epigenetic perspective.Biol Reprod，2009，81（4）：607-617

31.Liu J，Asuncion-Chin M，Liu P，et al.CaM kinase Ⅱ phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels.Nat Neurosci，2006，9：41-49

32.Lee YJ，Shukla SD.Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde.Eur J Pharmacol，2007，573：29-38

33.Liu Y，Balaraman Y，Wang G，et al.Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation.Epigenetics，2009，4：500-511

34.Lambert MP，Paliwal A，Vaissière T，et al.Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake.J Hepatol，2011，54：705-715

35.Miranda TB，Jones PA.DNA methylation：the nuts and bolts of repression.J Cell Physiol，2007，213：384-390

36.Muschler MA，Hillemacher T，Kraus C，et al.DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence.J Neural Transm，2010，117：513-519

37.Mandrekar P.Epigenetic regulation in alcoholic liver disease.World J GASTroenterol，2011，17（20）：2456-2464

38.Ouko LA，Shantikumar K，Knezovich J，et al.Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG-DMR in male gametes-implications for fetal alcohol spectrum disorders.Alcohol Clin Exp Res，2009，33（9）：1615-1627

39.Philibert RA，Gunter TD，Beach SR，et al.MAOA methylation is associated with nicotine and alcohol dependence in women.Am J Med Genet B Neuropsychiatr Genet，2008，147B：565-570

40.Pandey SC，Ugale R，Zhang H，et al.Brain chromatin remodeling： a novel mechanism of alcoholism.Neurosci，2008，28：3729-3737

41.Pietrzykowski AZ，Friesen RM，Martin GE，et al.Posttran-scriptional regulation 30.of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.Neuron，2008，59：274-287

42.Ponting CP，Oliver PL，Reik W.Evolution and functions of long noncoding RNAs.Cell，2009，136（4）：629-641

43.Park BY，Lee BC，Jung KH，et al.Epigenetic changes of serotonin transporter in the patients with alcohol dependence： methylation of an serotonin transporter promoter CpG island.Psychiatry Investig，2011，8（2）：130-133

44.Sathyan P，Golden HB，Miranda RC.Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure： evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium.J Neurosci，2007，27：8546-8557

45.Shukla SD，Lee YJ，Park PH，et al.Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes.Novartis Found Symp，2007，285：217-228

46.Shukla SD，Velazquez J，French SW，et al.Emerging role of epigenetics in the actions of alcohol.Alcohol Clin Exp Res，2008，32（9）：1525-1534

47.Tang Y，Banan A，Forsyth CB，et al.Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease.Alcohol Clin Exp Res，2008，32：355-364

48.Vaissière T，Sawan C，Herceg Z.Epigenetic interplay between histone modifications and DNA methylation in gene silencing.Mutat Res，2008，659：40-48

49.Wang Y，Ghezzi A，Yin JC，et al.CREB regulation of BK channel gene expression underlies rapid drug tolerance.Genes Brain Behav，2009，8：369-376

50.Zhou FC，Balaraman Y，Teng M，et al.Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation.Alcohol Clin Exp Res，2011，35（4）：735-746

51.Diako Charles，McMahon Kenneth，Mattinson Scott，et.al.Alcohol，Tannins，and Mannoprotein and their Interactions Influence the Sensory Properties of Selected Commercial Merlot Wines： A Preliminary Study.Journal of food science，2016，Vol.81（8）：S2039-S2048

52.María-Pilar Sáenz-Navajas，Campo E，José Miguel Avizcuri，et al.Contribution of nonvolatile and aroma fractions to in-mouth sensory properties of red wines： wine reconstitution strategies and sensory sorting task.Anal Chim Acta，2012.Jun 30； 732：64-72

53.Buch S，Stickel F，Trepo E，et al.A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.Nature Genetics.2015 Dec； 47（12）：1443-1448

54.Manchiero C，Nunes AKDS，Magri MC，et al.The rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C.BMC Infect Dis.2017 Dec 19； 17（1）：780

55.Rodrigues A，Ricardo-Da-Silva J M，Lucas C，et al.Effect of commercial mannoproteins on wine colour and tannins stability.Food Chemistry，2012，131（3）：907-914 7r21QHzcXEAwOVpcDOfADFPw32pg6d6R89miKWOexQfxHH/UfnYaDAWFADhOYJXp