第五节
展望

应用TBS宫颈细胞学报告系统的目的是提供一套全球统一的细胞病理学报告系统。不同实验室使用一致的检查结果命名系统，并可以在不同实验室和不同国家之间进行比较。在过去十多年，细胞病理学技术取得了许多重大进展，例如：液基细胞学、自动化标本制备、计算机辅助筛查、HPV检测、细胞学结合HPV检测筛查等，宫颈癌筛查指南也做了很大修改。HPV疫苗于2006年开始投入使用并被发达国家女性逐渐接受，将来宫颈癌及其癌前病变的发生率很可能会进一步降低。TBS系统自1988年建立以来，已于1991年、2001年被修订两次，2014年又第三次修订，将来必定还会被重新评价和修订，以适应宫颈癌研究、治疗、预防和筛查新技术的进展。

参考文献

[1] National Cancer Institute Workshop. The 1988 Bethesda System for reporting cervical/vaginal cytologic diagnoses. JAMA, 1989，262:931-934.

[2] The 1988 bethesda System for reporting cervical/vaginal cytologic diagnoses: Developed and approved at the national Institute Workshop in Bethesda, MD, December 12-13，1988. Diagn cytopathol, 1989，5:331-334.

[3] Kurman RJ, Solomon D. The Bethesda System for reporting cervical/vaginal cytologic diagnoses:Definitions, criteria and explanatory notes for terminology and specimen adequacy. New York: Springer-Verlag,1994.

[4] Sherman ME, Dasgupta A, Schiffman M, Nayar R,Solomon D. The Bethesda Interobserver Reproducibility Study（BIRST）: a web-based assessment of the Bethesda 2001 System for classifying cervical cytology. Cancer,2007，111（1）:15-25.

[5] Solomon D, Nayar R. The Bethesda System for reporting cervical cytology,2nd ed. New York:Springer, 2004.

[6] Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda System-terminology for reporting results of cervical cytology. JAMA, 2002，287:2114-2119.

[7] ASCCP consensus guidelines. Am J Obstet Gynecol,2007，197:346-355.

[8] Bibbo M and Wilbur D. Comprehensive Cytopathology. Third ed. Sauders, Elsevier, 2008，77-90.

[9] Halford JA, Batty T, Boost T, Duhig J, Hall J, Lee C, Walker K. Comparison of the Sensitivity of Conventional Cytology and the ThinPrep Imaging System for 1，083 Biopsy Confirmed High-Grade Squamous Lesions. Diagn. Cytopathol,2009.

[10] Karnon J, Peters J, Platt J, et al. Liquid-based cytology in cervical screening: an updated rapid and systematic review and economic analysis. Health Technol Assess,2004，8（20）:iii,1-78.

[11] Nayar R, Wilbur DC. The Bethesda System for Reporting Cervical Cytology. Third Edition. Springer 2015. exVca+ltdzpcr8sIkekuXR0+VkDkDMFTtJoEUi7a9PcN/3Ool09z/bJCZEUMEE07